Changes in renal cortical sialic acids and colloidal iron staining associated with exercise

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Abstract
The purpose of this study was to determine it exercise was associated with alterations in renal cortical sialie acid content or glomenilar capillary anionic character. These factors have been shown to be important, insofar as they contribute to an electrostatic barrier which prevents the filtration of negatively charged macromolecules. In unilaterally nephrectomized dogs (n=7), exercised kidneys tended to have increased amounts ol sialic acids and a decrease in glomcrular anionic character, as evaluated by the intensity of colloidal iron staining, however. nephrectomy alone also caused similar changes. Additional experiments were conducted using rat litter males assigned to control or treadmill-exercise groups, Exercised animals were run for 60-80 min. Renal cortical sialic acids were 2.71 ± 0.07 µmol/g for controls (n =12) and 3.03+0.09 µmol/g for the exercised animals (n=10) (P P <0.05). Colloidal iron staining remained below control levels for 24 h post-exercise. These data suggest that exercise increases glomerular sialic acid content and decreases colloidal iron staining. This latter effect may decrease the glomerular capillary electrostatic barrier and thereby max lie an important lactor in causing exercise proteinuria.