The antiinflammatory activity of IgG: the intravenous IgG paradox
Top Cited Papers
Open Access
- 16 January 2007
- journal article
- review article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 204 (1) , 11-15
- https://doi.org/10.1084/jem.20061788
Abstract
How high doses of intravenous IgG (IVIG) suppress autoimmune diseases remains unresolved. We have recently shown that the antiinflammatory activity of IVIG can be attributed to a minor species of IgGs that is modified with terminal sialic acids on their Fc-linked glycans. Here we propose that these Fc-sialylated IgGs engage a unique receptor on macrophages that, in turn, leads to the upregulation of an inhibitory Fcγ receptor (FcγR), thereby protecting against autoantibody-mediated pathology.Keywords
This publication has 34 references indexed in Scilit:
- Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levelsNature Biotechnology, 2005
- Siglecs in innate immunityCurrent Opinion in Pharmacology, 2005
- Clinical Outcome of Lymphoma Patients After Idiotype Vaccination Is Correlated With Humoral Immune Response and Immunoglobulin G Fc Receptor GenotypeJournal of Clinical Oncology, 2004
- The complement system in regulation of adaptive immunityNature Immunology, 2004
- Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular LymphomaJournal of Clinical Oncology, 2003
- IVIg-mediated amelioration of murine ITP via FcγRIIB is independent of SHIP1, SHP-1, and Btk activityBlood, 2003
- Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa geneBlood, 2002
- Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc ReceptorScience, 2001
- Fc RECEPTORS AND THEIR INTERACTIONS WITH IMMUNOGLOBULINSAnnual Review of Cell and Developmental Biology, 1996
- HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN FOR IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDHOODThe Lancet, 1981