THE RESPONSE OF ISOLATED SEGMENTS OF INTESTINE AND UTERUS TO ADRENALIN AT DIFFERENT pH LEVELS OF THE BATH

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Abstract
Isolated segments of duodenum, jejunum, and ileum of the rabbit show in most cases after equivalent additions of adrenalin to a bath of Locke''s solution at a Ph of 8.2 an earlier, greater, more rapid, and more prolonged depression of tonus with a slower recovery of the amplitude of rhythmical contractions than at a [rho]p H of 7.3. Rateof the rhythmical contractions is not affected by the drug at any [rho]H between 7.0 and 8.3. An optimum [rho]H for the depressant action of adrenalin on these tissues is thought to exist at about 7.8. Segments of scybalar colon show in most cases after equivalent additions of adrenalin to the bath at [rho]H of 8.3 a greater fall of tonus than at a [rho]H of 7.2. Recovery of depressed tonus and contractions is more rapid at a pa of 8.3 than at a ph of 7.2. Rate of rhythmical contractions is not affected by the drug at any [rho]H between 7.0 and 8.3. An optimum [rho]H for the depressant action of a minimal dose of adrenalin on the colon is thought to exist at about 7.3. Segments of non-pregnant rabbit''s uterus show no difference in response to minimal stimulatory doses of adrenalin at various [rho]H levels ranging from 7.0 to 8.3.

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