Inhibition of Vaccinia Virus Growth by the Nucleoside Analogue 1-beta-D-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, Ribavirin)
- 1 August 1976
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 32 (2) , 327-330
- https://doi.org/10.1099/0022-1317-32-2-327
Abstract
Summary Virazole or Ribavirin (1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) inhibits the growth of vaccinia virus at a concentration of 50 µg/ml. Although vaccinia virus DNA and polypeptides are made to a certain extent in the presence of Virazole, the DNA fails to acquire resistance to deoxyribonuclease and virus particles are not formed. Reversibility of the antiviral effect occurs when the drug is washed out from the infected cultures or when guanosine at an equimolar concentration is added.This publication has 2 references indexed in Scilit:
- Studies on the structural proteins of vaccinia virusVirology, 1967
- The replication and coating of vaccinia DNAJournal of Molecular Biology, 1964