MOBILITY OF LYMPHOCYTE SURFACE-MEMBRANE CONCANAVALIN A RECEPTORS OF NORMAL AND FELINE LEUKEMIA VIRUS-INFECTED VIREMIC FELINES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (3) , 956-959
Abstract
The virus-associated depression of concanavalin [Con] A mitogenesis which accompanies feline leukemia virus[FLV]-induced cat lymphoma was investigated by comparing lymphocyte surface receptor mobility of normal cats to that of viremic diseased animals. The mechanisms of feline lymphocyte receptor mobility were studied using fluorescein-conjugated Con A to quantitate lymphocyte capping. A study of 21 disease-free animals showed that cat lymphocytes undergo appreciable Con A capping, with a mean capping rate of 17%. Morphologically normal peripheral blood lymphocytes of 6 FLV-infected viremic cats, with or without lymphoma, exhibited a mean capping of only 7%, significantly less than that of the control animals (P < 0.005). A membrane-related lymphocyte deficiency may accompany the development of virus-induced lymphoma in the cat.

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