Human p53 gene localized to short arm of chromosome 17

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Abstract
The p53 gene codes for a nuclear protein that has an important role in normal cellular replication1–4. The concentration of p53 protein is frequently elevated in transformed cells1,2. Transfection studies show that the p53 gene, in collaboration with the activated ras oncogene, can transform cells5–7. Chromosomal localization may provide a better understanding of the relationship of p53 to other human cellular genes and of its possible role in malignancies associated with specific chromosomal rearrangements. A recent study mapped the human p53 gene to the long arm of chromosome. 17 (17q21–q22) using in situ chromosomal hybridization8. Here, by Southern filter hybridization of DNAs from human–rodent hybrids, we have localized the p53 gene to the short arm of human chromosome 17.