THE PHYSIOLOGIC SIGNIFICANCE OF THE SECRETION OF ENDOGENOUS INSULIN INTO THE PORTAL CIRCULATION. I. COMPARISON OF THE EFFECTS OF GLUCAGON-FREE INSULIN ADMINISTERED VIA THE PORTAL VEIN AND VIA A PERIPHERAL VEIN ON THE MAGNITUDE OF HYPOGLYCEMIA AND PERIPHERAL GLUCOSE UTILIZATION1

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Abstract
Sixteen experiments were performed on 8 dogs. In each dog during one experiment, glucagon-free insulin was administered via the portal vein to simulate the route traversed by endogenous insulin, and during the other, the same dose was administered into a peripheral vein in the foreleg. The endoportal administration of insulin resulted in the same degree of arterial hypoglycemia as the peripheral route of administration, and in a significantly reduced augmentation of peripheral glucose utilization as evidenced by changes in the arteriovenous glucose difference. These data suggest that a physiologic difference in the metabolic pattern, after insulin administration, occurs depending upon the route of administration.