Klinische und tierexperimentelle Untersuchungen zur Frage der serumallergischen in-vitro-Leukocytolyse

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Abstract
[lomg dash]In vitro leukocytolysis is increased not only in tuberculin- and pollen-allergy but also after the addition of the homologous foreign serum to blood of animals and men, in whom this foreign serum had been injected 10 or more days previously. The pathogenesis of this increased leukocytolysis may also be closely associated with the antigen-antibody-complex as shown by the temporal correspondence, the course of the cytolysis, the coincidence with other allergic manifestations and the reproducibility of the anaphylactic experiment in animals. In corresponding clinical controls, the increased leukocytolysis, therefore, must be considered as a hyperergic reaction of allergic pathogenesis. The leukocytic decomposition cells ("leukocytare Abbauzellen") represent the morphological manifestations of these perishing polymorphonuclear leukocytes. This cytolysis, like other isolated cellular phenomena of allepgic pathogenesis, does not occur in all cases. The increased in-vitro-leukocytolysis has a diagnostic value approximately comparable to that of blood eosinophilia.

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