The effect of ascorbic acid on the conjugation of 4-hydroxybiphenyl in rat isolated hepatocytes

Publisher Website
Google Scholar
Abstract
Ascorbic acid at high nonphysiological levels inhibited the sulfation of 4-hydroxybiphenyl by rat isolated hepatocytes. Glucuronylation of 4-hydroxybiphenyl, formed from 4-methoxybiphenyl, was increased at ascorbic acid levels which inhibited sulfation. The glucuronylation of 4-hydroxybiphenyl added directly to the cells was enhanced at concentrations of ascorbic acid which did not inhibit sulfation. Ascorbic acid did not influence the cytochrome P-450-dependent O-demethylation of 4-methoxybiphenyl or the level of cellular lipid peroxidation.