IN VITRO GENERATION OF HELPER T CELLS AND SUPPRESSOR T CELLS THAT REGULATE THE CYTOLYTIC T LYMPHOCYTE RESPONSE TO TRINITROPHENYL-MODIFIED SYNGENEIC CELLS
- 1 April 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 33 (4) , 422-426
- https://doi.org/10.1097/00007890-198204000-00016
Abstract
Helper T cells and suppressor T cells [from mice] were generated in vitro that regulate the cytolytic T lymphocyte (CTL) response to trinitrophenyl (TNP)-modified syngeneic cells. B6D2F1 helper cells generated to TNP-modified parental (P1) cells augment the CTL response to those P1-TNP-modified antigens but not to P2-TNP-modified antigens. The generation of these helper T cells requires the presence of splenic adherent cells; these helper T cells are radioresistant. A soluble factor can be obtained from the helper T cell cultures that can also augment the CTL response. The suppressor T cells generated in culture do not demonstrate the specificity observed with the helper T cells; however, they are antigen-dependent in their induction. Whether helper or suppressor activity is obtained depends upon the length of time cells are cultured in vitro.This publication has 7 references indexed in Scilit:
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