Discrimination between Messenger Ribonucleic Acids by a Mammalian Translation Initiation Factor

Open Access

1 July 1973

journal article
research article
Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences

Vol. 70 (7) , 2139-2144
https://doi.org/10.1073/pnas.70.7.2139

Abstract

A factor from rabbit-reticulocyte ribosome, which stimulates by 5-fold initiation of hemoglobin mRNA translation in Krebs ascites cell extracts, was purified to homogeneity. The factor, a protein of about 65,000 molecular weight in sodium dodecyl sulfate, discriminates between various mRNAs: it stimulates translation of α globin mRNA and of tobacco mosaic virus RNA, but has only a small effect on β globin mRNA and no effect at all on Mengo virus RNA translation.

Keywords

This publication has 22 references indexed in Scilit:

Stimulation by reticulocyte initiation factors of protein synthesis in a cell-free system from Krebs II ascites cells
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972
Specific inhibitors of MS2 and late T4 RNA translation in E. coli
Biochemical and Biophysical Research Communications, 1972
Initiation of globin synthesis
FEBS Letters, 1972
Myosin synthesis and specificity of eukaryotic initiation factors
Biochemistry, 1972
Characterization of cistron specific factors for the initiation of messenger RNA translation inE. coli
FEBS Letters, 1972
Mammalian Cell‐Free Protein Synthesis Directed by Viral Ribonucleic Acid
European Journal of Biochemistry, 1970
Role of initiation factor B (F3) in the preferential translation of T4 late messenger RNA in T4 infected E. Coli
FEBS Letters, 1970
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
Nature, 1970
Control of Specific Gene Expression in Higher Organisms
Science, 1969
Release of messenger RNA from rabbit reticulocyte polyribosomes at low concentration of divalent cations
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967