Experimentally induced complement and immunoglobulin deposition along the basement membrane zone (BMZ) and in dermal blood vessels

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Abstract
Clinically normal forearm skin of 10 subjects was abraded and biopsied at 24 h and at 5 and 10 day intervals. Biopsy specimens were processed for routine histology and direct immunofluorescence. All 10 subjects showed deposition of complement either in the blood vessels and/or along the basement membrane zone [BMZ] 24 h after injury. IgM deposition was found along the BMZ in 2 patients and in the blood vessels of the papillary dermis in 1 patient. This immunofluorescence staining was considered a non-specific reaction pattern to injury.