Two-dimensional electrophoresis of peptides from human-CHO cell hybrids containing human chromosome 21
- 1 November 1983
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 9 (6) , 687-697
- https://doi.org/10.1007/bf01539474
Abstract
Peptide expression influenced by human chromosome 21 was examined by comparing two-dimensional electrophoretograms of a human-hamster hybrid cell containing human chromosome 21 with its parent hamster cell and a revenant of the hybrid which had segregated the chromosome 21 genes for SOD-1, GARS, and a cytotoxic cell-surface antigen. Certain peptides were found in the hybrid but not in the hamster cell. Some, but not all, of these peptides segregated with markers for chromosome 21. Hamster peptides were also found which apparently were suppressed in the hybrid. Finally, one peptide was identified which was unique to the revertant cell. These findings may be of potential relevance to Down's syndrome.Keywords
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