Gel Double Diffusion Studies with Group B and Group A, Type 9 Coxsackie Viruses

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Abstract
Summary: The demonstration by the gel double diffusion technique of “specific” precipitating antibodies for the Coxsackie viruses suggests that the method offers considerable promise for use in the laboratory diagnosis of infections due to virus types A9, B1, B3, B4, B5 and possibly B6. Patients with Coxsackie B2 virus infections, however, could not be shown to develop “specific” precipitating antibody. “Specific” precipitating antibodies for the infecting virus type were found in the sera of 97% of patients from whom a Coxsackie A9, B1, B3, B4, B5 or B6 virus was isolated and in 40 to 65% of these patients “specific” precipitating antibody developed over the course of the illness. However, since “specific” precipitating antibody disappears relatively rapidly during convalescence, its presence in any serum specimen may be evidence of a current or very recent infection. Heterotypic “specific” precipitating antibody was absent in 78% of the patients who yielded a Coxsackie virus, and when present would appear to be due to recent infection with the heterotypic virus, or to anamnestic response.

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