Pressure-volume response of isolated living main pulmonary artery in dogs

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Abstract
Isolation of the main pulmonary artery by obturation of the right and left branches under conditions which maintained vasal circulation to the wall was achieved by extracorporeal circulation. Pressure-volume response of the segment was measured directly using a reciprocating essentially sinusoidal volume input at rates of 90, 45, and 180 cycles/min. Using volumes which generated physiologic pressures, a steady-state response starting from rest occurred in 300—500 cycles. At steady state the pressure-volume response was linear and unchanged by these cycling rates. The relaxation pattern during the initial phase was consistent with a single mode of response and closely duplicated the stress-relaxation pattern of a single noncycled input of the same volume. In 34 experiments in 11 animals steady-state volume distensibility (DeltaV x 100/V0 DeltaP) was 2.51% cm H2O. Segment geometry was preserved by luminal casting. An ellipsoidal configuration was apparent in the distended state. pulmonary-artery distensibility; mechanical behavior of arteries; stress-relaxation; geometry of arteries; tethering; viscoelastic properties of arteries; dynamic elastic response; coefficient of distensibility Submitted on June 16, 1964

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