Vincristine Neurotoxicity

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Abstract
To the Editor: Vincristine (Oncovin) is an effective chemotherapeutic agent widely used in the treatment of various neoplastic diseases. Among its more attractive features is the virtual absence of bone-marrow toxicity, allowing full dosage to be given in combination with bone-marrow suppressive agents. Indeed, the limiting toxicity of vincristine is neuro-logic, primarily peripheral and autonomic neuropathy.1 , 2 Although this fact is well appreciated by all who use the drug, we are not aware of any previous reports of particular sensitivity to vincristine among patients with pre-existing neurologic deficits. We therefore wish to describe the occurrence of fatal neurotoxicity in a patient . . .

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