The reformatsky reaction of 1‐acyl‐3,5‐dimethylpyrazoles. A convenient preparation of 4‐amino‐3‐oxoalkanoic acid derivatives

Publisher Website
Google Scholar
Abstract
The conversion of N‐acylpyrazoles into β‐keto esters was accomplished efficiently by the treatment with α‐bromo esters and zinc dust. Using this Reformatsky reaction of N‐acylpyrazoles, 4‐(protected amino)‐3‐oxoalkanoic acid derivatives were conveniently prepared as the key intermediates in the synthesis of statines.