Comparative Study of Total Urinary Oestrogen and First Morning Urinary Oestrogen in Monitoring Gonadotrophin Therapy

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Abstract
Total 24-h urinary estrogen has been used extensively and proven to be reliable in monitoring gonadotropin therapy for induction of ovulation. However, the method is time consuming for the patient and incomplete collection, as expected, is not uncommon, hence interfering with the treatment result. Estrone 3-glucuronide in 1st morning urine samples has been shown to correlate well with plasma estradiol-17 .beta. levels during normal menstrual cycles. A comparative study was made to examine the correlation between the levels of 24-h urinary estrogen and 1st morning urinary estrogen in patients on gonadotropin therapy. Creatinine levels were also determined to exclude the factor of variable excretion of estrogen. The correlation thus found is highly significant (P < 0.001). Hence 1st morning urinary estrogen to creatinine ratios may be used to replace 24-h urinary estrogen in biochemical monitoring of gonadotropin therapy.