Synthesis and Antimicrobial Activity of Pyridines Bearing Thiazoline and Moieties.
- 1 January 1998
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 46 (5) , 863-866
- https://doi.org/10.1248/cpb.46.863
Abstract
Two series of new pyridines bearing thiazoline (3a--n) and thiazolidinone (5a--e) moieties were prepared via the cyclization of the corresponding substituted pyridyl thiourea (2a--g) with an appropriately substituted phenacyl bromide or chloroacetic acid, respectively. The antimicrobial activity was determined for representative compounds and most of them showed moderate activity against Gram-positive bacteria.Keywords
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