A Hierarchical Bayesian Model to Predict the Duration of Immunity toHaemophilus InfluenzasType B
- 1 December 1999
- journal article
- Published by Oxford University Press (OUP) in Biometrics
- Vol. 55 (4) , 1306-1313
- https://doi.org/10.1111/j.0006-341x.1999.01306.x
Abstract
Summary.A hierarchical Bayesian regression model is fitted to longitudinal data onHaemophilus influenzaetype b (Hib) serum antibodies. To estimate the decline rate of the antibody concentration, the model accommodates the possibility of unobserved subclinical infections with Hib bacteria that cause increasing concentrations during the study period. The computations rely on Markov chain Monte Carlo simulation of the joint posterior distribution of the model parameters. The model is used to predict the duration of immunity to subclinical Hib infection and to a serious invasive Hib disease.Keywords
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