Antitumor activity of derivatives of mycophenolic acid.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (3) , 275-285
- https://doi.org/10.7164/antibiotics.29.275
Abstract
One hundred and eight derivatives of mycophenolic acid (MA) from Penicillium were prepared by modifications at the phenolic hydroxyl and/or carboxyl sites. None of these compounds was as effective as MA in suppressing cell growth of L-5178Y leukemia cells in vitro, whereas several compounds with changes at the hydroxyl and carboxyl groups were more effective than MA against Ehrlich solid carcinoma and L-1210 leukemia in mice.This publication has 0 references indexed in Scilit: