The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis
- 1 February 2000
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 6 (2) , 189-195
- https://doi.org/10.1038/72294
Abstract
Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER-2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu-overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.Keywords
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