Template-directed oligomerization of 3-isoadenosine 5′-phosphate
- 1 June 1988
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 27 (2) , 91-95
- https://doi.org/10.1007/bf02138366
Abstract
Template-directed oligomerization of an activated derivative of 3-isoadenosine 5′-phosphate (piA) on polyuridylic acid [poly(U)] was studied. The reaction of ImpiA is more efficient than the corresponding reaction of ImpA, and produces 3′–5′-linked oligomers while the reaction of ImpA gives only 2′–5′-linked oligomers. The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.Keywords
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