The effect of premature and delayed birth on the development of UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone in the rat
- 15 February 1980
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 186 (2) , 617-619
- https://doi.org/10.1042/bj1860617
Abstract
In the rat, UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone increase markedly after normal or premature birth. This rapid development is superimposed upon a much slower maturation of activity which occurs in utero during the last 2 days of normal gestation and gestation when birth is delayed. Development of all three activities is similar under these different conditions, suggesting a common developmenpal regulatory mechanism.This publication has 3 references indexed in Scilit:
- DIFFERENTIAL STIMULATION OF HEPATIC MONO-OXYGENASE AND GLUCURONIDATING SYSTEMS IN CHICK-EMBRYO AND NEONATAL RAT BY GLUCOCORTICOIDS1979
- Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substratesBiochemical Journal, 1978
- Precocious development of UDP-glucuronyltransferase activity in chick-embryo liver after administration of adrenocorticotropic hormone and of certain 11β-hydroxy corticosteroidsBiochemical Journal, 1976