Drosophila melanogaster Thor and Response to Candida albicans Infection
- 1 April 2007
- journal article
- Published by American Society for Microbiology in Eukaryotic Cell
- Vol. 6 (4) , 658-663
- https://doi.org/10.1128/ec.00346-06
Abstract
We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans . Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E - BP null mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection.Keywords
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