Purified Flagella from Treponema phagedenis Biotype Reiter Does Not lnduce Protective Immunity against Experimental Syphilis in Rabbits

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Abstract
Thirteen rabbits were immunized 3 times at weekly intervals with 50 .mu.g of flagella purified from T. phagedenis biotype Reiter. Fourteen rabbits were inoculated in the same way with a placebo preparation. Rabbits immunized with the flagella developed an immune response to the flagella, but showed no statistically significant prolongation of incubation time or diminution of lesion severity when challenged intradermally with 4 .times. 103 T. pallidum organisms.