Radiation Protection of Mouse Liver by 2-Mercaptopropionylglycine

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Abstract
The present study is an attempt to investigate the protection imparted by MPG (2-mercaptopropionylglycine) to liver in Swiss albino mice against damages caused by external irradiation. The histopathological changes in the liver of a group of mice exposed to 1000 R of Co-60 gamma rays 15-30 minutes after an intraperitoneal injection of 20 mg/kg body weight of MPG were studied at different post-irradiation intervals. The results were compared with those received from a control group which was irradiated in the absence of the drug. The MPG was found to provide ample protection to the liver leading to an accelerated recovery and restoring the normal structure by 4 weeks after irradiation.

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