Angiotensin converting enzyme inhibitors produced by Streptomyces chromofuscus. Discovery, taxonomy and fermentation.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (8) , 997-1002
- https://doi.org/10.7164/antibiotics.38.997
Abstract
Culture A58365.1 NRRL 15098, identified as a new strain of Streptomyces chromofuscus, was found to produce two novel angiotensin converting enzyme (ACE) inhibitors, A58365A and A58365B. Fermentation medium studies afforded an increase in ACE inhibitor titers from less than 1 .mu.g/ml to greater than 20 .mu.g/ml. Proline was the obligatory supplement for ACE inhibitor biosynthesis.This publication has 0 references indexed in Scilit: