INVESTIGATION OF EFFECT OF K-ANTIGEN IN ESCHERICHIA-COLI URINARY-TRACT INFECTIONS BY USE OF A MOUSE MODEL

  • 1 January 1975
    • journal article
    • research article
    • Vol. 56  (6) , 549-553
Abstract
Urinary infection could be produced in mice by the inoculation of E. coli into the bladder, provided that sutures were first inserted into the bladder wall to act as foreign bodies. The bladder was almost always infected; the kidneys were involved less often. The frequency of kidney infection was directly proportional to the amount and activity of the K antigen of the infecting strain of E. coli. The significance of K antigens in relation to host defense mechanisms and tissue invasion is discussed.