Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice
- 1 October 1977
- journal article
- research article
- Published by Taylor & Francis in Aihaj Journal
- Vol. 38 (10) , 509-522
- https://doi.org/10.1080/0002889778507665
Abstract
Mice were exposed to various concentrations of formaldehyde or acrolein. Concentration-response relationships were developed by measuring per cent decrease in respiratory rate, indicating upper respiratory tract sensory irritation. Relationships are presented between the concentration associated with a 50% respiratory decrease and TLVs. A summary of other animal inhalation studies is presented. The basis for the acrolein and formaldehyde TLVs are reviewed. Mice exposed for 4 days showed increasing sensitivity daily for both compounds. A re-evaluation of the TLVs is suggested.This publication has 8 references indexed in Scilit:
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