Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction
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Open Access
- 1 January 2008
- journal article
- Published by Springer Nature in Particle and Fibre Toxicology
- Vol. 5 (1) , 1
- https://doi.org/10.1186/1743-8977-5-1
Abstract
We have shown that pulmonary exposure to fine particulate matter (PM) impairs endothelium dependent dilation in systemic arterioles. Ultrafine PM has been suggested to be inherently more toxic by virtue of its increased surface area. The purpose of this study was to determine if ultrafine PM (or nanoparticle) inhalation produces greater microvascular dysfunction than fine PM. Rats were exposed to fine or ultrafine TiO2 aerosols (primary particle diameters of ~1 μm and ~21 nm, respectively) at concentrations which do not alter bronchoalveolar lavage markers of pulmonary inflammation or lung damage.Keywords
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