Specificity in the hydrolysis of N-acyl-L-phenylalanine 4-nitroanilides by chymotrypsin
- 1 September 1980
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 36 (9) , 1039-1040
- https://doi.org/10.1007/bf01965954
Abstract
The affinity of N-acyl-L-phenylalanine 4-nitroanilides for chymotrypsin is enhanced as the hydrophobicity of non-amino acid residues in the P2-position of the substrates increases, whereas kcat remains nearly constant. On the other hand, if alanine or leucine is in the P2-position kcat increases with decreasing KM.This publication has 18 references indexed in Scilit:
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