Zn2+ inhibits the anion transport activity of Band 3 by binding to its cytoplasmic tail
- 1 August 1994
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 14 (4) , 159-169
- https://doi.org/10.1007/bf01200245
Abstract
Zn2+ can induce a conformational change of Band 3 with concomitant inhibition of its anion transport activity of human erythrocyte membrane vesicles only from the cytoplasmic side. The Zn2+ inhibition exhibits a dose-dependent manner with an apparent half maximal concentration of 50 μM ZnCl2 and can be reversed by 0.5 mM EDTA, but not by 1 mM dithiothreitol. The Zn2+ effect is specific and no similar inhibitory action could be observed by other divalent cations (Cu2+, Mn2+, Mg2+ or Sr2+).Keywords
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