Prostaglandins, Indomethacin and the Decidual Cell Reaction in the Mouse Uterus

Publisher Website
Google Scholar
Abstract
A uterine decidual cell reaction (DCR) was induced in hormone-primed ovariectomized mice by injection of 10 µl of sesame oil or by crushing 1 uterine horn with hemostats (trauma). Either stimulation led to a rapid elevation (within 15 min) of the cAMP level in the stimulated horn. Rapid proliferation of decidual cells began 30 h after stimulation. Oil stimulation also resulted in a 6-fold increase in cGMP levels in both the stimulated and unstimulated uterine horns within 15 min. Pretreatment with indomethacin blocked the oil-induced cyclic nucleotide increases and the subsequent DCR. Pretreatment with indomethacin did not, however, completely prevent the increase in cAMP and decidualization in the uterine horns stimulated by crushing.