Massive and Prolonged Administration of Iron-Dextran Complex

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Abstract
THE development of sarcomas in rats after the repeated administration of massive doses of iron-dextran complex has been reported by Richmond1 and confirmed by Haddow and Horning.2 The latter were able to demonstrate the same phenomenon in mice and, to a very minor degree, in hamsters. In approximately two thirds of the rats and mice (86 of 130) given weekly subcutaneous injections of iron-dextran complex§ spindle-cell sarcomas developed at the injection site in the ensuing six to eighteen months. It must be noted that the weekly dose in these studies was several times the animal's body content of iron, or . . .