A new interface to couple thin‐layer chromatography with laser desorption/atmospheric pressure chemical ionization mass spectrometry for plate scanning
- 6 September 2005
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 19 (19) , 2789-2793
- https://doi.org/10.1002/rcm.2120
Abstract
An interface to allow on‐line qualitative and quantitative full‐plate detection and analysis of compounds separated by thin‐layer chromatography (TLC) is presented. A continuous wave diode laser is employed as a desorption source. Atmospheric pressure chemical ionization mass spectrometry ionizes and subsequently identifies the desorbed sample molecules. Besides direct laser desorption on untreated TLC plates, graphite particles were used as a matrix to couple in the laser power and improve the efficiency of desorption. Copyright © 2005 John Wiley & Sons, Ltd.Keywords
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