A Novel Approach to the Microdosimetry of Neutron Capture Therapy. Part I. High-Resolution Quantitative Autoradiography Applied to Microdosimetry in Neutron Capture Therapy

1 October 1995

journal article
Published by JSTOR in Radiation Research

Vol. 144 (1) , 50-8
https://doi.org/10.2307/3579235

Abstract

A novel approach to the microdosimetry of neutron capture therapy has been developed using high-resolution quantitative autoradiography (HRQAR) and two-dimensional Monte Carlo simulation. This approach has been applied using actual cell morphology (nuclear and cytoplasmic cell structures) and the measured microdistribution of boron-10 in a transplanted murine brain tumor (GL261) containing p-boronophenylalanine (BPA) as the boron compound. The 2D Monte Carlo transport code for the alpha and 7Li charged particles from the 10B(n,alpha)7Li reactions has been developed as a surrogate to a full 3D approach to calculate a variety of different microdosimetric parameters. The HRQAR method and the surrogate 2D Monte Carlo approach are described in detail and examples of their use are presented.

Keywords

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