ORAL GLUCOSE-TOLERANCE TEST IN CYNOMOLGUS MONKEY (MACACA-FASCICULARIS)

  • 1 January 1976
    • journal article
    • research article
    • Vol. 26  (5) , 771-776
Abstract
[Spontaneous diabetes mellitus-like disease has been found in various species of the old-world monkey. This disease is generally characterized by hyperglycemia, glucosuria, an abnormal glucose tolerance curve (GTC) and an impaired insulin response.] The glucose tolerance test was simplified, so that it could be performed on more than 1 cynomolgus monkey (M. fascicularis) at a time. Glucose was administered orally in a dose of 2 g/kg body wt as a 50% aqueous solution, and blood samples were taken just before and 30 min and 150 min after glucose administration. The simplified test was conducted on 93 cynomolgus monkeys. Glucose tolerance curves obtained by this method were classified into 3 patterns with regard to the increasing rate of serum glucose concentration per min and the decreasing rate. Seventy-one monkeys showed the 1 pattern characterized by an increasing rate of 1.0 mg/min or more and a decreasing rate of 0.2 mg/min or more. The 2nd pattern showing an increasing rate of 1.0 mg/min or more and a decreasing rate of less than 0.2 mg/min was found in 10 monkeys. The remaining 12 monkeys exhibited the 3 pattern in which the increasing rate and the decreasing rate were less than 1.0 mg/min and 0.2 mg/min, respectively. The 1st pattern is probably normal glucose tolerance, while the 2nd and 3rd patterns are probably abnormal ones. The incidence of the abnormal patterns was significantly higher in wild-imported cynomolgus monkeys than in laboratory bred monkeys.

This publication has 0 references indexed in Scilit: