The purification and development of a radioimmunoassay for β-core fragment of human chorionic gonadotrophin in urine: application as a marker of gynaecological cancer in premenopausal and postmenopausal women

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Abstract
The β-core fragment of human chorionic gonadotrophin (hCG) is a major part of the immunoreactive hCG-like material found in the urine of normal pregnant women. Patients with non-trophoblastic gynaecological malignancies have been found to have raised levels of urinary β-core. We describe the purification of β-core, the preparation of a polyclonal sheep antiserum and the development of radioimmunoassay. The minimum detection limit of this assay was 0·025 μg β-core/l. There was no significant cross-reaction with the free α-subunit, hLH, hFSH and hTSH (Journal of Endocrinology (1991) 130, 481–489

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