Inhibition of Bovidae Oocyte Meiosis by Serine Protease Inhibitors

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Abstract
Specific inhibitors of serine proteases were shown for the 1st time to inhibit meiotic progression in mammalian oocytes, suggesting involvement of these enzymes in the process of maturation [The specific site directed inhibitors for trypsin, N-p-tosyl-L-lysine chloromethyl ketone; for chymotrypsin, N-p-tosyl-L-phenylalanine chloromethyl ketone, elastase and acetylalanyl alanyl pyrolyl alanine chloro-methyl ketone; the trypsin substrate analog N-tosyl-arginine methyl ester HCl; the inhibitor of esterases involved in the photophosphorylation of serine residues in their active centers, phenyl-methyl sulfonyl fluoride; and the specific chymotrypsin inhibitor, diphenyl carbamyl chloride, were studied.].

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