Origin of Cerebrospinal Fluid Gamma Globulin in Subacute Sclerosing Leukoencephalitis

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Abstract
ONE of the characteristic features of subacute sclerosing leukoencephalitis (SSLE) is a prominent elevation of cerebrospinal fluid (CSF) γ-globulin concentration.1In this study we have attempted to define the origin of the excess γ-globulin in the CSF. The exchange of gamma G globulin (IgG) labeled with radioactive iodine (125I) between the serum and CSF has been examined in two patients with SSLE and in three control subjects with normal CSF γ lin concentrations. In addition, the rate of flux of γ-globulin into the CSF was measured during ventriculolumbar perfusion of chemotherapeutic agents. Methotrexate was administered by the intraventricular route to two patients with pontine gliomas, and 5-iododeoxyuridine (IUDR) was administered to two patients with SSLE in an attempt to modify the course of these generally fatal diseases. Results were obtained which suggest that immunoglobulin is synthesized within the nervous system in SSLE. Report of Cases CASE 1.—This

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