A Study of the Interaction between Oxytetracycline and Pyridostigmine
- 1 May 1988
- journal article
- research article
- Published by SAGE Publications in Human Toxicology
- Vol. 7 (3) , 263-266
- https://doi.org/10.1177/096032718800700306
Abstract
1 Oxytetracycline and pyridostigmine were given alone and in combination for 4 days to 12 normal male volunteers in a double-blind, randomised cross-over study. On the fifth day, the pharmacokinetic profiles of the two drugs were examined, and blood and plasma cholinesterase activity was measured. 2 No significant interaction on absorption or pharmacokinetics of either drugs was detected when they were given in combination. 3 There was a small but statistically significant increase in erythrocyte cholinesterase when oxytetracycline was given in combination with pyridostigmine, the pharmacological significance of which is not clear.This publication has 6 references indexed in Scilit:
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