EFFECT OF DEHYDRATION ON ERYTHROPOIESIS IN MICE - RELEVANCE TO ANEMIA OF SPACE-FLIGHT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 49  (8) , 990-993
Abstract
Mice deprived of water for 24 h showed an increase in hematocrit and loss of body weight comparable to that seen in men during space flight. Increase in hematocrit was entirely due to a decrease in plasma volume and was associated with suppression of erythropoiesis, but with no significant change in the serum titer of a presumptive humoral regulator of erythropoiesis, erythroid stimulating activity (ESA). Mice deprived of water for 24 h may be a useful model for study of early hematological effects of space flight. Suppression of erythropoiesis due to a relative erythrocytosis appears to be independent of ESA.