Somatostatin Inhibits Urinary Cyclic AMP Excretion in Diabetic Rats

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Abstract
Short term (30 min) infusion of cyclic [c] somatostatin (50 .mu.g/rat), insulin (1 U[unit]/rat) or the 2 together significantly suppressed urinary cAMP excretion in streptozotocin-diabetic rats. While somatostatin tended to increase cGMP excretion, insulin had an opposite effect in diabetic but not in normal rats. Somatostatin may suppress cAMP excretion by inhibiting directly adenylate cyclase in liver and perhaps in other organs. The possibility that suppression of urinary cAMP is due to inhibition of glucagon secretion is also considered.