Lecithin: cholesterol acyltransferase activity in rats treated with 4-amino-pyrazolo-pyrimidine
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 38 (7) , 643-647
- https://doi.org/10.3109/00365517809102430
Abstract
Lecithin:cholesterol acyltransferase (LCAT) in rats treated with 4-amino-pyrazolo-pyrimidine (4-APP) has been studied. Treatment with 4-APP decreased the plasma concentration of triglycerides, cholesterol and cholesteryl ester concomitantly with a decreased rate of cholesterol esterification in plasma. The reduced cholesterol esterification was due both to an effect on the enzyme and on the lipoprotein substrate. Plasma prothrombin decreased to the same extent as that of LCAT, indicating that the primary effect of 4-APP is upon protein synthesis and secretion from the liver.Keywords
This publication has 21 references indexed in Scilit:
- The intestine as a source of apolipoprotein A1.Proceedings of the National Academy of Sciences, 1977
- Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.Proceedings of the National Academy of Sciences, 1977
- Regulation of sterol synthesis in adrenal gland of the rat by both high and low density human plasma lipoproteinsBiochemical and Biophysical Research Communications, 1976
- Discoidal bilayer structure of nascent high density lipoproteins from perfused rat liver.Journal of Clinical Investigation, 1976
- Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.Proceedings of the National Academy of Sciences, 1976
- Receptor-Mediated Control of Cholesterol MetabolismScience, 1976
- Cholesterol Esterification and Lipids in Plasma and Liver from Newborn and Young Guinea Pigs Raised on Milk and Non-Milk DietAnnals of Nutrition and Metabolism, 1975
- Purification and substrate specificity of lecithin—cholesterol acyl transferase from human plasmaFEBS Letters, 1971
- Synthesis and destruction of prothrombin in the ratArchives of Biochemistry and Biophysics, 1969
- Effect of heparin on in vivo turnover of clotting factorsJournal of Applied Physiology, 1960