Altered Mechanisms of Vasodilation in Aged Human Skin
- 1 July 2007
- journal article
- review article
- Published by Wolters Kluwer Health in Exercise and Sport Sciences Reviews
- Vol. 35 (3) , 119-125
- https://doi.org/10.1097/jes.0b013e3180a02f85
Abstract
Human skin blood flow increases in response to increased body core and local skin temperature via distinct reflex and local mechanisms requiring functional nitric oxide (NO) for full expression. The mechanisms mediating cutaneous vasodilation are impaired with primary aging, resulting in attenuated vasodilation. This article highlights recent findings of how age-related vascular impairments in NO signaling contribute to attenuated cutaneous vasodilation.Keywords
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