The role of cyclin E in the regulation of entry into S phase
- 1 January 1995
- book chapter
- Published by Springer Nature
- Vol. 1, 125-139
- https://doi.org/10.1007/978-1-4615-1809-9_10
Abstract
Cyclin E is a crucial regulator of entry into S phase in higher eukaryotes and acts in association with the protein kinase cdk2. Cyclin E expression is transcriptionally controlled in mammalian cells resulting in a maximum just before entry into S phase. Premature expression of cyclin E advances entry into S phase, while lack of cyclin E prevents entry into S phase. Cyclin E/cdk2 activity is regulated at multiple levels (by transcription, phosphorylation and inhibitor proteins) and appears to be involved in triggering initiation of DNA replication and in regulating genes important for proliferation and progression through S phase.Keywords
This publication has 132 references indexed in Scilit:
- Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinasesPublished by Elsevier ,1994
- Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complexCell, 1994
- Differential regulation of E2F transactivation by cyclin/cdk2 complexes.Genes & Development, 1994
- Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinaseCell, 1994
- Tumor suppressor genesCurrent Opinion in Genetics & Development, 1994
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Nature, 1993
- Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factorThe Journal of cell biology, 1993
- Cyclin-dependent kinase 2 (cdk2) in the murine cdc2 kinaseTS mutantSomatic Cell and Molecular Genetics, 1992
- ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexNature, 1992
- Involvement of p34cdc2 in establishing the dependency of S phase on mitosisNature, 1991