Experimental Tooth Transplantation in the Rhesus Monkey

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Abstract
Forty autologously transplanted mandibular incisors of 20 Rhesus monkeys were studied histologically and roentgenographically 4 days to 11 months postoperatively. Initially noted was coagulation necrosis of the pulpal tissue and loss of odontoblasts with osteoid formation at the apex. There was gradual replacement of the necrotic tissue in the pulpal canal by ingrowth of connective tissue elements presumably arising from the organizing blood clot. In later specimens, osteodentin had filled the coronal region of the pulp. Apically there was normal pulpal tissue with active odontoblasts forming tubular dentin. Periodontal fibers were normal with elements from both host and donor forming the ultimate periodontal ligament. The continued viability of the pulpal cells near the apex was considered significant in the reappearance of odontoblasts. Hertwig''s sheath performed its natural function of extending root growth. Thirty-five of the 40 autotransplants were considered successful.

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