2-Amino-2-oxazolines as Subtype Selective α2 Adrenoceptor Agonists
- 18 April 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 43 (9) , 1699-1704
- https://doi.org/10.1021/jm9905256
Abstract
Cyclohexylamino oxazoline 1 (AGN 190837), an analogue of 2 (Bay a6781), is a potent α2 adrenoceptor agonist. On the basis of a design generated by receptor−ligand modeling, a number of cyclohexyl and norbornyl analogues were synthesized wherein the propyl group of 1 was replaced by phenylalkyl subsituents. This resulted in compound 6 being an α2c selective agonist, as well as 7 and 9 being α2a/α2c selective.Keywords
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