Some solution properties of pentagastrin and angiotensin: aggregation of pentagastrin

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Abstract
Pentagastrin and angiotensin have been studied in the presence and absence of urea by light-scattering, viscosity, dialysis, surface tension and other physicochemical techniques for evidence of peptide aggregation. Pentagastrin forms large linear, flexible aggregates (molecular weight 40 000) in phosphate buffer above a concentration of ∼0·1 g dl−1 and in solutions shows time-dependent flow behaviour. Angiotensin shows no evidence of aggregation beyond dimers. In 1m urea the pentagastrin is in the form of dimers.